Pittsburgh and West Virginia are both looking to become bowl eligible while Penn State closes out its seasons this weekend.
The Pittsburgh Panthers will aim to keep their bowl eligibility hopes alive when they take on the Rutgers Scarlet Knights as part of a loaded holiday weekend of college football action.
With four wins on the year and two games remaining, the Panthers will need to win both their Saturday meeting with Rutgers and next weekend's showdown with the South Florida Bulls to become bowl-eligible.
Elsewhere, the Penn State Nittany Lions will hit the field for the final time in 2012, as their season ends with a conference showdown against the Wisconsin Badgers.
The West Virginia Mountaineers, also looking to gain bowl eligibility take on the Iowa State Cyclones in a Friday afternoon meeting.
Here's the weekend's key games from the Big 12, Big Ten and Big East:
West Virginia Mountaineers vs. Iowa State Cyclones, Nov. 23, 3:30 p.m. ET, ABC
Michigan Wolverines vs. Ohio State Buckeyes, Nov. 24, 12 p.m. ET, ABC
Michigan State Spartans vs. Minnesota Golden Gophers, Nov. 24, 3:30 p.m. ET, Big Ten Network
Oklahoma State Cowboys vs. Oklahoma Sooners, Nov. 24, 3:30 p.m. ET, ESPN
Wisconsin Badgers vs. Penn State Nittany Lions, Nov. 24, 3:30 p.m. ET, ESPN2