The St. Louis Cardinals couldn't put together many hits in their last matchup with the Pittsburgh Pirates when A.J. Burnett was on the mound, but in the second matchup against Burnett he struggled to get the Cardinals out in the top of the first inning. The first four batters in the Cardinals lineup each picked up a hit off Burnett and they each scored.

The first run was driven in by Matt Holliday, who singled to left field driving in Rafeal Furcal. The very next batter, Carlos Beltran, hit a bomb to left field for a three-run home run to give the Cardinals an early 4-0 lead in the first inning.

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