Pittsburgh's opening drive ended abruptly when Antoine Bethea stepped in front of Ben Roethlisberger's first pass for an interception. The Steelers held Luck to a three and out on their opening possession and the Steelers took the ball back deep in their own territory. After a couple of Roethlisberger passes netted a first down, he hooked up with wideout Antonio Brown for a 57 yard touchdown.
Roethlisberger completed 5 of 7 passes for 81 yards with a touchdown and an interception. Jonathan Dwyer finished the quarter with four carries for 14 yards while Brown had two catches for 75 yards.
Andrew Luck had a much tougher first quarter than last week against the Rams, going 6 of 12 for 76 yards and an interception. Reggie Wayne has two catches for 23 yards for the Colts.