Johnny Cueto pitched six strong innings for the Reds, while Jeff Karstens pitched seven innings and allowed three runs, one earned, in the loss.
Errors by Pirates rookie shortstop Chase D'Arnaud led to runs for the Reds in the first and fifth innings. They also scored in the second, when Karstens walked Jay Bruce, who came around to score on a sacrifice fly by Miguel Cairo.
The Pirates' only run came in the fourth. Neil Walker was hit by a pitch, and Andrew McCutchen brought him home with a double.
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