Gonzalez didn't pitch in last week's series. He's been a big part of the Nationals' resurgence this year, striking out 50 batters in 41.2 innings so far. Bedard might have his hands full keeping up with him.
Bedard, meanwhile, returns after missing a start due to back spasms.
Since the Pirates and Nationals' last series, one of the bigger stories surrounding the Nats has been Stephen Strasburg's struggles in his last start, and the unusual reason for them -- he somehow got Hot Stuff ointment in his groin. The Pirates, perhaps fortunately, will miss Strasburg in this brief two-game set. After Gonzalez on Wednesday, James McDonald and the Bucs will take on Jordan Zimmermann on Thursday at 7:05 before heading to Detroit for an interleague series against the Tigers.