Expecting to be without both safety Troy Polamalu and linebacker James Harrison, the Steelers will have a showdown with the 0-2 Raiders, who lost 35-13 to the Miami Dolphins in Week 2.
Without Polamalu and Harrison, the Steelers were able to keep the Jets in check and have a bye week in Week 4.
Other key games from around the AFC North to keep an eye on:
The week's marquee matchup is also its Sunday night showdown as the pair of 1-1 teams square off in primetime.
Cincinnati's defense will be tested against Redskins quarterback Robert Griffin III.
The Browns are the AFC North division's only 0-2 squad, and will look to get their first win at home against the Bills to keep up with the rest of the division.
For more Pittsburgh Steeler coverage, check out Behind the Steel Curtain.